PlantTFDB
Plant Transcription Factor Database
v4.0
Previous version: v3.0
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID AT1G01380.1
Common NameETC1, F6F3.18
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Family MYB_related
Protein Properties Length: 83aa    MW: 9831.22 Da    PI: 7.5234
Description MYB_related family protein
Gene Model
Gene Model ID Type Source Coding Sequence
AT1G01380.1genomeTAIRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1Myb_DNA-binding28.73e-093672644
                     HHHHHHHHHHHHHTTTT-HHHHHHHHTTTS-HHHHHHHH CS
  Myb_DNA-binding  6 teEdellvdavkqlGggtWktIartmgkgRtlkqcksrw 44
                     +eE++l+ +  k+ G + W++Ia +++ gRt++++  +w
      AT1G01380.1 36 QEEEDLICRMYKLVGER-WDLIAGRIP-GRTAEEIERFW 72
                     7**************99.*********.********999 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SMARTSM007176.8E-63078IPR001005SANT/Myb domain
CDDcd001675.09E-63672No hitNo description
SuperFamilySSF466892.85E-73675IPR009057Homeodomain-like
Gene3DG3DSA:1.10.10.609.9E-113673IPR009057Homeodomain-like
PfamPF002494.9E-83673IPR001005SANT/Myb domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006357Biological Processregulation of transcription from RNA polymerase II promoter
GO:0080147Biological Processroot hair cell development
GO:1900033Biological Processnegative regulation of trichome patterning
GO:0005634Cellular Componentnucleus
GO:0000981Molecular FunctionRNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0001135Molecular Functiontranscription factor activity, RNA polymerase II transcription factor recruiting
GO:0043565Molecular Functionsequence-specific DNA binding
GO:0044212Molecular Functiontranscription regulatory region DNA binding
Plant Ontology ? help Back to Top
PO Term PO Category PO Description
PO:0000037anatomyshoot apex
PO:0000263anatomynon-hair root epidermal cell
PO:0000293anatomyguard cell
PO:0009005anatomyroot
PO:0020100anatomyhypocotyl
Sequence ? help Back to Top
Protein Sequence    Length: 83 aa     Download sequence    Send to blast
MNTQRKSKHL KTNPTIVASS SEEVSSLEWE EIAMAQEEED LICRMYKLVG ERWDLIAGRI  60
PGRTAEEIER FWVMKNHRRS QLR
Expression -- Microarray ? help Back to Top
Source ID E-value
GEO1453349461e-141
Genevisible257490_x_at1e-138
Expression AtlasAT1G01380-
AtGenExpressAT1G01380-
ATTED-IIAT1G01380-
Expression -- Description ? help Back to Top
Source Description
UniprotTISSUE SPECIFICITY: Expressed in developing trichomes and non-root hair cells. {ECO:0000269|PubMed:15063185, ECO:0000269|PubMed:15584952}.
Functional Description ? help Back to Top
Source Description
TAIRETC1 is involved in trichome and root hair patterning in Arabidopsis.
UniProtMYB-type transcription factor involved in epidermal cell fate specification. Acts as a negative regulator of trichome development, by mediating lateral inhibition. Promotes the formation of hair developing cells in H position in root epidermis, probably by inhibiting non-hair cell formation. {ECO:0000269|PubMed:15063185, ECO:0000269|PubMed:15584952}.
Function -- GeneRIF ? help Back to Top
  1. Mutations in CPC or TRY delay flowering of cpl3 plants. A mutation in ETC1 did not further delay flowering but reduced plant size.
    [PMID: 23796522]
  2. In an intricate interplay between three partly redundant single R3 MYB proteins, CPC, ETC1, and TRY regulate several developmental, physiological and metabolic processes that are putatively located in different tissues.
    [PMID: 26022254]
  3. Data show that both transcript levels and expression patterns of ENHANCER OF TRIPTYCHON AND CAPRICE1 (ETC1) in the root tip were affected in hda6 mutation.
    [PMID: 26143251]
Cis-element ? help Back to Top
SourceLink
PlantRegMapAT1G01380.1
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Regulation -- ATRM (Manually Curated Upstream Regulators) ? help Back to Top
Source Upstream Regulator (A: Activate/R: Repress)
ATRM AT1G63650 (A), AT3G27920 (A), AT5G14750 (A), AT5G41315 (A)
Regulation -- ATRM (Manually Curated Target Genes) ? help Back to Top
Source Target Gene (A: Activate/R: Repress)
ATRM AT1G79840(R)
Interaction -- BIND ? help Back to Top
Source Intact With Description
BINDAT1G63650EGL3 interacts with ETC1 (At1g01380).
Interaction ? help Back to Top
Source Intact With
IntActSearch Q9LNI5
Phenotype -- Mutation ? help Back to Top
Source ID
T-DNA ExpressAT1G01380
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAY5195181e-139AY519518.1 Arabidopsis thaliana MYB transcription factor (At1g01380) mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_171645.11e-55MYB-like transcription factor ETC1
SwissprotQ9LNI51e-57ETC1_ARATH; MYB-like transcription factor ETC1
TrEMBLR0IP836e-50R0IP83_9BRAS; Uncharacterized protein
STRINGAT1G01380.13e-55(Arabidopsis thaliana)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM32328194
Representative plantOGRP4207823
Publications ? help Back to Top
  1. Riechmann JL, et al.
    Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes.
    Science, 2000. 290(5499): p. 2105-10
    [PMID:11118137]
  2. Kirik V,Simon M,Huelskamp M,Schiefelbein J
    The ENHANCER OF TRY AND CPC1 gene acts redundantly with TRIPTYCHON and CAPRICE in trichome and root hair cell patterning in Arabidopsis.
    Dev. Biol., 2004. 268(2): p. 506-13
    [PMID:15063185]
  3. Serna L
    A network of interacting factors triggering different cell fates.
    Plant Cell, 2004. 16(9): p. 2258-63
    [PMID:15342905]
  4. Zimmermann IM,Heim MA,Weisshaar B,Uhrig JF
    Comprehensive identification of Arabidopsis thaliana MYB transcription factors interacting with R/B-like BHLH proteins.
    Plant J., 2004. 40(1): p. 22-34
    [PMID:15361138]
  5. Montiel G,Gantet P,Jay-Allemand C,Breton C
    Transcription factor networks. Pathways to the knowledge of root development.
    Plant Physiol., 2004. 136(3): p. 3478-85
    [PMID:15542499]
  6. Esch JJ,Chen MA,Hillestad M,Marks MD
    Comparison of TRY and the closely related At1g01380 gene in controlling Arabidopsis trichome patterning.
    Plant J., 2004. 40(6): p. 860-9
    [PMID:15584952]
  7. Serna L
    Epidermal cell patterning and differentiation throughout the apical-basal axis of the seedling.
    J. Exp. Bot., 2005. 56(418): p. 1983-9
    [PMID:15967776]
  8. Morohashi K, et al.
    Participation of the Arabidopsis bHLH factor GL3 in trichome initiation regulatory events.
    Plant Physiol., 2007. 145(3): p. 736-46
    [PMID:17885086]
  9. Simon M,Lee MM,Lin Y,Gish L,Schiefelbein J
    Distinct and overlapping roles of single-repeat MYB genes in root epidermal patterning.
    Dev. Biol., 2007. 311(2): p. 566-78
    [PMID:17931617]
  10. Tominaga R, et al.
    Arabidopsis CAPRICE-LIKE MYB 3 (CPL3) controls endoreduplication and flowering development in addition to trichome and root hair formation.
    Development, 2008. 135(7): p. 1335-45
    [PMID:18305006]
  11. Zhao M,Morohashi K,Hatlestad G,Grotewold E,Lloyd A
    The TTG1-bHLH-MYB complex controls trichome cell fate and patterning through direct targeting of regulatory loci.
    Development, 2008. 135(11): p. 1991-9
    [PMID:18434419]
  12. Wang S, et al.
    Comprehensive analysis of single-repeat R3 MYB proteins in epidermal cell patterning and their transcriptional regulation in Arabidopsis.
    BMC Plant Biol., 2008. 8: p. 81
    [PMID:18644155]
  13. Shangguan XX,Xu B,Yu ZX,Wang LJ,Chen XY
    Promoter of a cotton fibre MYB gene functional in trichomes of Arabidopsis and glandular trichomes of tobacco.
    J. Exp. Bot., 2008. 59(13): p. 3533-42
    [PMID:18711121]
  14. Wester K, et al.
    Functional diversity of R3 single-repeat genes in trichome development.
    Development, 2009. 136(9): p. 1487-96
    [PMID:19336467]
  15. Kang YH, et al.
    The MYB23 gene provides a positive feedback loop for cell fate specification in the Arabidopsis root epidermis.
    Plant Cell, 2009. 21(4): p. 1080-94
    [PMID:19395683]
  16. Marks MD,Wenger JP,Gilding E,Jilk R,Dixon RA
    Transcriptome analysis of Arabidopsis wild-type and gl3-sst sim trichomes identifies four additional genes required for trichome development.
    Mol Plant, 2009. 2(4): p. 803-22
    [PMID:19626137]
  17. Bruex A, et al.
    A gene regulatory network for root epidermis cell differentiation in Arabidopsis.
    PLoS Genet., 2012. 8(1): p. e1002446
    [PMID:22253603]
  18. Tominaga-Wada R,Nukumizu Y
    Expression analysis of an R3-Type MYB transcription factor CPC-LIKE MYB4 (TRICHOMELESS2) and CPL4-Related transcripts in Arabidopsis.
    Int J Mol Sci, 2012. 13(3): p. 3478-91
    [PMID:22489163]
  19. Meinke DW
    A survey of dominant mutations in Arabidopsis thaliana.
    Trends Plant Sci., 2013. 18(2): p. 84-91
    [PMID:22995285]
  20. Tominaga-Wada R,Nukumizu Y,Sato S,Wada T
    Control of plant trichome and root-hair development by a tomato (Solanum lycopersicum) R3 MYB transcription factor.
    PLoS ONE, 2013. 8(1): p. e54019
    [PMID:23326563]
  21. Chandrika NN,Sundaravelpandian K,Yu SM,Schmidt W
    ALFIN-LIKE 6 is involved in root hair elongation during phosphate deficiency in Arabidopsis.
    New Phytol., 2013. 198(3): p. 709-20
    [PMID:23432399]
  22. Nukumizu Y,Wada T,Tominaga-Wada R
    Tomato (Solanum lycopersicum) homologs of TRIPTYCHON (SlTRY) and GLABRA3 (SlGL3) are involved in anthocyanin accumulation.
    Plant Signal Behav, 2013. 8(7): p. e24575
    [PMID:23603939]
  23. Tominaga-Wada R,Nukumizu Y,Wada T
    Flowering is delayed by mutations in homologous genes CAPRICE and TRYPTICHON in the early flowering Arabidopsis cpl3 mutant.
    J. Plant Physiol., 2013. 170(16): p. 1466-8
    [PMID:23796522]
  24. Jin J, et al.
    An Arabidopsis Transcriptional Regulatory Map Reveals Distinct Functional and Evolutionary Features of Novel Transcription Factors.
    Mol. Biol. Evol., 2015. 32(7): p. 1767-73
    [PMID:25750178]
  25. Chen CY,Schmidt W
    The paralogous R3 MYB proteins CAPRICE, TRIPTYCHON and ENHANCER OF TRY AND CPC1 play pleiotropic and partly non-redundant roles in the phosphate starvation response of Arabidopsis roots.
    J. Exp. Bot., 2015. 66(15): p. 4821-34
    [PMID:26022254]
  26. Li DX,Chen WQ,Xu ZH,Bai SN
    HISTONE DEACETYLASE6-Defective Mutants Show Increased Expression and Acetylation of ENHANCER OF TRIPTYCHON AND CAPRICE1 and GLABRA2 with Small But Significant Effects on Root Epidermis Cellular Pattern.
    Plant Physiol., 2015. 168(4): p. 1448-58
    [PMID:26143251]